She’s a film director who made a movie called Desperately Seeking Susan in 1985. It’s a caper that revolves around mistaken identity that stars Rosanna Arquette and a then unknown Madonna. Seidelman went on to direct She Devil with Meryl Streep in her first comedic role and Roseanne Barr performing in her first feature film. But Hollywood is a tough place for women directors. Nora Ephron came on the scene and directed Sleepless in Seattle and You’ve Got Mail in the 1990s. And 25 years later Greta Gerwig had a big hit with Barbie. Seidelman eventually started working in TV, directing the pilot episode of a series that was to become a cultural icon, Sex and the City. She’s written a memoir called Desperately Seeking Something. We talk about sexism, ageism and the challenge of staying on top of your game.